English Version
淀粉样蛋白降解及抑制剂研究
* 双功能抑制剂的设计
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Liu Qian‡, Wu Wei-hui‡, Fang Chuan-lin, Li Ren-wang, Lei Peng, Hu Jia, Sun Xun, Zheng Yi-zhe, Zhao Yu-fen and Yan-Mei Li*
“Mapping ApoE/Abeta Binding Regions to Guide Inhibitor Discovery”
Molecular BioSystems    2011, 7, pp1693-1700
* Abeta/APOE相互作用的抑制剂
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Wu WH‡, Lei P‡, Liu Q, Hu J, Gunn A, Chen MS, Rui YF, Su XY, Xie ZP, Zhao YF, Bush A I*, Yan-Mei Li* 
“Sequestration of copper from β-amyloid promotes selective lysis by cyclen-hybrid cleavage agents”
Journal of Biological Chemistry   283(46), 2008, p31657-31664 (Highted by Nature China)
* hIAPP抑制剂的设计
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 Jia Hu‡, Ye-Ping Yu‡, Wei Cui, Chuan-Lin Fang, Wei-Hui Wu, Yu-Fen Zhao and Yan-Mei Li*
“Cyclen-Hybrid Compound Captures Copper to Protect INS-1 Cells from Islet Amyloid Polypeptide Cytotoxicity by Inhibiting and Lysing Effects”
Chemical Communication     2010, 46 (42), pp8023-8025
* 共价抑制剂的设计
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 Jing-Wen Ma, Lei Zhao, De-Sheng Zhao, Qian Liu, Chong Liu, Wei-Hui Wu, Yong-Xiang Chen, Yu-Fen Zhao and Yan-Mei Li*
“Covalently reactive group-modified peptide that specifically reacts with lysine16 in amyloid beta”
Chemical Communication     2012, 48(85), 10565-10567